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Medications

Compounded semaglutide

Semaglutide activates the GLP-1 receptor, slowing gastric emptying and reducing appetite. Dosed as a once-weekly injection (or, as Rybelsus, a daily oral tablet for a lower-potency use case), started low and titrated upward.

At a glance
Active ingredient
Semaglutide
Brand-name equivalents
Ozempic, Wegovy, Rybelsus
Drug class
GLP-1 receptor agonist

What the trials show

STEP 1
68 weeks, adults with obesity or overweight, 2.4mg once weekly vs. placebo
Mean weight reduction of 14.9% vs. 2.4% on placebo
2.4 mg−14.9%Placebo−2.4%
STEP 1 — mean weight reduction from baseline, % of body weight
Wilding et al., NEJM 2021 (NEJMoa2032183) ↗
SELECT
17,604 adults with established cardiovascular disease and overweight/obesity, without diabetes, 2.4mg once weekly vs. placebo, median follow-up 34 months
20% reduction in the composite of cardiovascular death, non-fatal heart attack, or non-fatal stroke vs. placebo — the trial that established a cardioprotective indication beyond weight lossLincoff et al., NEJM 2023 (DOI 10.1056/NEJMoa2307563) ↗

Trial results describe the active ingredient studied in its branded, FDA-approved form. Compounded versions use the same active ingredient but aren't themselves the studied, FDA-approved product — see our compounding pharmacy glossary entry.

Clinics we've profiled offering it

BelleDoctor-prescribed GLP-1s and longevity therapies, delivered directly to your door. No insurance. No waiting rooms. Just results.Big Easy Weight LossScale down to level up your healthBreeze MedsMedically supervised, effortless weight loss that's personalizedBrello HealthOne price, no surprisesCoby HealthGLP-1 Weight Loss Treatments Designed for YouDefy MedicalNot disclosedEdenLook, feel and perform your best every day.Fifty 410Your health glow-up, delivered. Science-backed treatments without the clinic vibes.FitnessRxGLP-1 + Fitness & Nutrition (Fitness RX, a new chapter powered by Body FX)FrameworkA precision wellness platform uniting science, personalization, and lifestyle design to optimize metabolism, enhance longevity, and unlock human potential.FridaysFridays (joinfridays.com) is a telehealth weight-loss platform operated by Thrive Health Group Inc. that prescribes compounded and brand-name GLP-1 medications via licensed providers and ships from partner compounding pharmacies.Gala Health (Gala GLP-1)Doctor-trusted GLP-1 for Weight LossGimmeGLP-1 medication, made easyGOAL.MDReal doctors. Better care. Exceptional results.Good Life MedsBringing Quality Care Home, 100% OnlineHenry MedsYour Health, Simplified. Affordable, personalized care from the comfort of your home.HimsWeight loss that works. GLP-1s, a personal plan, and access to ongoing care from day 1.Ivim HealthIndividualized Health & Wellness ProgramsJoin PomegranateExpert Care for a Healthier, More Confident YouMochi HealthGLP-1 weight-loss telehealth. Compounded medication, pharmacy chosen in-app.Orderly MedsGLP-1 weight-loss telehealth. Routes to 503A partner pharmacies.Refills.comGLP-1 Weight Loss, ED & Hair Treatments Prescribed OnlineReflexMDWeight Management at Your FingertipsRiftPersonalized GLP-1 Weight Loss Treatment OnlineShedGLP-1 weight-loss telehealth. Names its pharmacy partners in its terms.SkinnyRxCompounded GLP-1 weight loss medication, doctor-prescribed, delivered to your door.Synergy RxMedically supervised, effortless weight loss that's personalizedTake10RxStay active for Life with Modern MedicineTom Weight Loss ClinicOnline medical weight loss, made simpleTravaA journey ahead of you. A team behind you.Trillium MedsTransparent Telehealth Access for GLP-1 CareTrim RxGLP-1 weight-loss telehealth. The compounding pharmacy is not named.Trimi HealthPrescription weight loss, made simple.